First results for network identification

I just run the network with the linear model with saturation, and all conductances equal to 1. Then, I ablate neurons one by one, and see the change in the target neurons. I am looking for the following network:

>> M=conectividad2matrizsistema(todas.A_chem,todas.A_ej,todas.GABA,1,1,1);

Initial conditions, the sensory neurons activated:

>> find(strcmpi(todas.nombres,’aser’))
ans =
41
>> find(strcmpi(todas.nombres,’asel’))
ans =
40
>> V0=zeros(279,1);
>> V0([40 41])=1;

Target neurons:

>> find(strcmpi(todas.nombres,’avar’))
ans =
55
>> find(strcmpi(todas.nombres,’aval’))
ans =
54
>> find(strcmpi(todas.nombres,’avbl’))
ans =
56
>> find(strcmpi(todas.nombres,’avbr’))
ans =
57
>> resultados=matrizsistema2experimentoablacion(M,V0,500,.005,[-1 1],54:57);
>> plot(resultados)

The highest peaks are for the target neurons. Zoom:


The high peaks around 40 are the target neurons, but the other high peak are other neurons:

>> todas.nombres(find(mean(resultados,2)>4*10^-3 & mean(resultados,2)<10^-2))
ans =
‘AIBL’
‘AIBR’
‘ASEL’
‘ASER’

AIB, that plays a central role in the network. As we lower the threshold, we find more and more neurons in the network, and also some which are not:

>> todas.nombres(find(mean(resultados,2)>1*10^-3 & mean(resultados,2)<10^-2))
ans =
‘AIBL’
‘AIBR’
‘AIYL’
‘AIYR’
‘AIZL’
‘AIZR’
‘ASEL’
‘ASER’
‘AVEL’
‘AVER’
‘PVCL’
‘PVCR’
‘RIBL’
‘RIML’
‘RIMR’

We catch 7 out of 15 neurons in the network (counting laterally doubled neurons, excluding sensory and target neurons). 6 neurons are not in the network.

>> todas.nombres(find(mean(resultados,2)>.5*10^-3 & mean(resultados,2)<10^-2))
ans =
‘AIAL’
‘AIAR’
‘AIBL’
‘AIBR’
‘AIYL’
‘AIYR’
‘AIZL’
‘AIZR’
‘ASEL’
‘ASER’
‘AVDR’
‘AVEL’
‘AVER’
‘DVA’
‘FLPL’
‘PVCL’
‘PVCR’
‘RIBL’
‘RIBR’
‘RIML’
‘RIMR’
‘SAAVL’
‘VA08’

We catch 11 out of 15 neurons. 10 neurons are not in the network.

>> todas.nombres(find(mean(resultados,2)>.4*10^-3 & mean(resultados,2)<10^-2))
ans =
‘AIAL’
‘AIAR’
‘AIBL’
‘AIBR’
‘AIYL’
‘AIYR’
‘AIZL’
‘AIZR’
‘AS07’
‘ASEL’
‘ASER’
‘AVDL’
‘AVDR’
‘AVEL’
‘AVER’
‘AWCL’
‘DVA’
‘DVC’
‘FLPL’
‘PVCL’
‘PVCR’
‘RIBL’
‘RIBR’
‘RIFR’
‘RIML’
‘RIMR’
‘SAAVL’
‘VA08’
‘VB09’

We catch 13 out of 15 neurons. 14 neurons are not in the network.

 

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